Titre :	Computational network pharmacology and virtual screening analysis of chemical constituents of plants used in the traditional drink "Al-Jur" against COVID-19 and seasonal respiratory diseases
Type de document :	document multimédia
Auteurs :	Aida Tahri, Auteur ; Nadjoua Tifouri, Auteur ; Ahmed Boufissiou, Directeur de thèse ; Youcef Boubrima, Directeur de thèse
Editeur :	Laghouat : Université Amar Telidji - Département de biologie
Année de publication :	2025
Importance :	184 p.
Accompagnement :	1 disque optique numérique (CD-ROM)
Note générale :	Option : Pharmacotoxicology
Langues :	Anglais (eng)
Mots-clés :	Al-Jur tea  Medicinal plants  Bioactive compounds  Computational network pharmacology  Respiratory diseases  COVID-19
Résumé :	This study combines computational network pharmacology and virtual screening to evaluate the therapeutic potential of the traditional multi-herb beverage "Al-Jur" against COVID-19 and other respiratory infections. Traditionally used to treat respiratory and digestive disorders, "Al-Jur" is analyzed here for its key bioactive compounds and their pharmacological interactions. Using systems-level pharmacology tools, interactions between phytochemicals and disease- related protein targets were mapped, with particular focus on COVID-19 and other respiratory pathogens. In parallel, bioactive compounds were virtually screened against these targets to assess binding affinities and potential inhibitory effects. Results suggest that the compounds from "Al-Jur" act on a network of functionally related proteins, influencing entire biological pathways rather than single molecular targets. These findings support the potential of this traditional remedy as a multi-target therapeutic candidate for managing respiratory infections, including COVID-19.
note de thèses :	Mémoire de master en sciences biologiques

Computational network pharmacology and virtual screening analysis of chemical constituents of plants used in the traditional drink "Al-Jur" against COVID-19 and seasonal respiratory diseases [document multimédia] / Aida Tahri, Auteur ; Nadjoua Tifouri, Auteur ; Ahmed Boufissiou, Directeur de thèse ; Youcef Boubrima, Directeur de thèse . - Laghouat : Université Amar Telidji - Département de biologie, 2025 . - 184 p. + 1 disque optique numérique (CD-ROM).
Option : Pharmacotoxicology
Langues : Anglais (eng)

Mots-clés :	Al-Jur tea  Medicinal plants  Bioactive compounds  Computational network pharmacology  Respiratory diseases  COVID-19
Résumé :	This study combines computational network pharmacology and virtual screening to evaluate the therapeutic potential of the traditional multi-herb beverage "Al-Jur" against COVID-19 and other respiratory infections. Traditionally used to treat respiratory and digestive disorders, "Al-Jur" is analyzed here for its key bioactive compounds and their pharmacological interactions. Using systems-level pharmacology tools, interactions between phytochemicals and disease- related protein targets were mapped, with particular focus on COVID-19 and other respiratory pathogens. In parallel, bioactive compounds were virtually screened against these targets to assess binding affinities and potential inhibitory effects. Results suggest that the compounds from "Al-Jur" act on a network of functionally related proteins, influencing entire biological pathways rather than single molecular targets. These findings support the potential of this traditional remedy as a multi-target therapeutic candidate for managing respiratory infections, including COVID-19.
note de thèses :	Mémoire de master en sciences biologiques